Cabinet notes · Lyon
Five cabinet notes. One nitrate shelf.
open the label, then the mailbag
Tadalafil 10 mg as needed, sildenafil 100 mg after a light plate, vardenafil 10 mg after a QT pass, finasteride 1 mg for hair, amoxicillin 875 mg as a finished course. Jovin writes those locks from the prescribing information. Nothing is sold.
How a note is filed
Open, dose, mail, file
The order is the same on every page. The labelled milligram comes before price. The nitrate hold, the QT line, or the allergy card comes before a fill conversation. Rosalind Hartley answers the mailbag last, then the page is dated.
Open
The current FDA label first, then a named trial if a number in the text needs one. Marketing copy is not a source.
Dose
One labelled lock per page: 10 mg as needed, 100 mg, 10 mg after QT, 1 mg daily, or 875 mg as a course. The rest of the ladder can be named; the SERP lock stays still.
Reader letters under the remedy, answered in Rosalind's voice, pointed at the same label. Not a clinic visit.
File
A dated review, a freshness stamp, and a link to the cabinet disclaimer. If the label moves, the page moves.
Field notes
The questions people type before they open a full remedy
Shorter than a remedy page. One note per medicine: whether a 10 mg Cialis tablet covers tomorrow, what a first 100 mg night does to the clock, what to expect from a 10 mg Levitra start, the hair questions on Propecia 1 mg, and how to take Amoxil 875 mg without stopping early.
A 10 mg Cialis tablet can still be useful tomorrow
Thirty-six hours is a readiness window, not a day and a half of erection. Lilly's US label starts most men at 10 mg as needed and …
Cabinet notePropecia 1 mg is a three-month verdict, not a weekend one
Week twelve on Propecia 1 mg is the earliest DailyMed will call a benefit. Men still open a search bar at week six and treat a bat…
Field noteThe first 100 mg night follows the plate, then the clock
Dinner decides more first nights than the milligram on the foil. Pfizer's label allows sildenafil with or without food, then admit…
Cabinet noteFourteen 875 mg tablets only work if you finish them
A twice-daily 875 mg pack is fourteen tablets if the prescriber wrote a week. People feel human on day three and leave the last ei…
Field noteA 10 mg Levitra start waits on the QT line
Before a 10 mg Levitra tablet I ask about the QT line. The dedicated study in middle-aged men found a mean QTcF rise of 8 msec aft…
The journal
Three PDE5 clocks on one spread
The comparison puts tadalafil 10 mg, sildenafil 100 mg and vardenafil 10 mg side by side on onset, food, QT and the shared nitrate hold. Read it before you pick a remedy page by brand colour.
The cabinet
Five remedy pages, each with its own lock
A full write-up per molecule: mechanism, the locked milligram, the holds that stop a night or a course, and a mailbag. The fill insert at the end prices a real US count. Jovin does not dispense.
Take the 100 mg sildenafil tablet after the plate is clear
Pfizer's 100 mg diamond is the top of the Viagra ladder, not the labelled start. Most men on the US PI begin at 50 mg about an hour before sex, with r…
Open the remedy → 5-alpha-reductase inhibitorGive Propecia 1 mg three months before you judge the vertex
Daily Propecia 1 mg is the hair pack this cabinet files. The US insert asks for one tablet a day, with or without food, and for three months or more b…
Open the remedy → Aminopenicillin antibioticAn 875 mg amoxicillin course is finished, not abandoned mid-week
An 875 mg amoxicillin course is a twice-daily bacterial job, not a mid-week experiment. The US table uses 875 mg every 12 hours for severe ear, sinus,…
Open the remedy → PDE5 inhibitorA 10 mg tadalafil tablet can cover tomorrow after the nitrate shelf
Open the cabinet with the nitrate question, not the marketing clock. A labelled 10 mg tadalafil tablet, sold as Cialis, is the as-needed start on the …
Open the remedy → PDE5 inhibitorClear the QT line, then the labelled 10 mg vardenafil start
Levitra's usual adult start is 10 mg about 60 minutes before sex, once daily at most. Rise to 20 mg or drop to 5 mg by effect and side effects. Brand …
Open the remedy →The practitioner
One Lyon GP signs every cabinet note
Dr. Rosalind Hartley reviews each page and answers the mailbag. Nitrates and PDE5 tablets never mix. A penicillin allergy is not a footnote. An antibiotic course is finished or stopped by a clinician, not by a webpage.
Research centres
The labs and regulators the notes draw on
Sandwich, Bothell, Wuppertal, Rahway, Brockham Park, Silver Spring, Amsterdam. The history is here so the locks on the remedy pages have somewhere to point.
Former Pfizer Discovery Laboratories
Ramsgate Road, Sandwich, Kent CT13 9NJ, United Kingdom
The Kent site where sildenafil started out as UK-92,480, a hopeful angina candidate. The heart numbers were dull; the notes patients kept making about erections were not, and Pfizer turned the whole programme toward erectile dysfunction. Most of the modern PDE5 story opens on this road.
ICOS Corporation (historic)
22021 20th Avenue SE, Bothell, WA 98021, USA
The Washington biotech that worked out tadalafil and partnered with Eli Lilly to carry it through late trials. Its molecule left the body far more slowly than its rivals, and that one pharmacokinetic quirk became Cialis — the long-window tablet the category now measures itself against.
Bayer AG
Aprather Weg 18a, 42113 Wuppertal, Germany
The Wuppertal laboratories behind vardenafil, later sold as Levitra and the orodispersible Staxyn. Its compound is the most potent PDE5 inhibitor per milligram of the three, which is why the labelled doses read so much smaller than sildenafil's.
Merck Research Laboratories
126 East Lincoln Avenue, Rahway, NJ 07065, USA
The New Jersey labs that developed finasteride, first as the prostate drug Proscar and then, at a fifth of the dose, as Propecia for male-pattern hair loss. The insight came from studying men born without working 5-alpha-reductase — a natural experiment that pointed straight at the enzyme.
Beecham Research Laboratories (historic)
Brockham Park, Betchworth, Surrey RH3 7AJ, United Kingdom
The Surrey research site where Beecham chemists built the semisynthetic penicillins, amoxicillin among them, in the early 1970s. Adding a single hydroxyl group to ampicillin gave a molecule the gut absorbs far better — the reason amoxicillin, not ampicillin, sits in most medicine cabinets today.
U.S. Food and Drug Administration
10903 New Hampshire Avenue, Silver Spring, MD 20993, USA
The American regulator whose approved prescribing information sets the doses, boxed cautions and interaction rules we quote. When a page here and the current FDA label disagree, the label is the authority — the nitrate contraindication for the PDE5 drugs above all.
European Medicines Agency
Domenico Scarlattilaan 6, 1083 HS Amsterdam, Netherlands
The EU agency whose scientific assessments and product information sit beside the FDA label in our reading. Its reviews are especially useful for the European brands and for the reasoning behind each approved indication.
Last Updated
Jovin Med
Five medicines, written up like an apothecary would — plainly, and with the label kept open.
honest notes, never a sales pitch
Open the cabinet